药物化学学部
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赵钟祥
发布时间:2019-10-02      来源:药物化学学部       点击:

2A804

 

赵钟祥

职称/职务:教授/副院长
邮箱地址:zzx37@gzucm.edu.cn
联系电话:(+86) 020-39358072

简介

赵钟祥,男,博士,教授,博士生导师,bat365官网登录副院长,广东省高校优秀青年教师培养对象,广州市首批珠江科技新星。1997-2006年于华中科技大学获学士和博士学位;2006年7月起至今就职于bat365官网登录,主要从事中药药效物质及作用机制方面的教学和研究工作。近年来主持、参研国家级、省市级科研项目13项,其中主持国家自然科学基金课题4项,以第一作者/通讯作者在Organic Letters、Chemical Communications、Phytomedicine、Journal of Natural Products、Phytochemistry、Journal of Ethnopharmacology等领域高影响期刊发表论文40余篇。

教育及工作经历

1. 1997.09 - 2001.06  华中科技大学同济医学院 学士学位

2. 2001.09 - 2006.06  华中科技大学同济医学院 博士学位

3. 2006.07 - 至今 bat365官网登录工作

研究方向

基于组分体内过程、代谢组学等新策略的中药药效物质及作用机制研究;源于中药及天然产物的药源分子发现及成药性评价。

科研及教学课题

1. 国家自然科学基金面上项目,2021.1-2024.12,主持

2. 国家自然科学基金面上项目,2017.1-2020.12,主持

3. 国家自然科学基金面上项目,2012.1-2016.12,主持

4. 国家自然科学基金青年项目,2010.1-2012.12,主持

5. 学科协同创新团队重点项目,2021.1-2023.12,主持

6. 广东省自然科学基金,2019.10-2022.9,主持

7. 广东省科技计划项目,2017.1-2019.12,主持

8. 广东省优秀青年教师培养计划项目,2014.1-2016.12,主持

9. 广东省自然科学基金项目,2009.8-2011.8,主持

10. 广州市珠江科技新星专项,2011.11-2014.11,主持

承担的课程

《中药化学》,《天然药物化学》,《药学导论》等。

代表性成绩

1. 培养研究生8人获国家奖学金、1人获省优秀研究生、2人获李时珍奖学金、3人获校优秀毕业生;指导本科生10人获校优秀毕业论文。

2. 获广东省优秀青年教师培养对象、珠江科技新星、学校教学先进个人和科研先进个人。

3. 副主编《中药化学》十四五规划教材1部,参编规划教材3部。

4. 参获得广东省教学成果一等奖1项、二等奖1项,广州中医药大学教学成果特等奖1项、一等奖2项。

代表性论文论著

1. Ruan QF, Pan WC, Zhao M, Tang YQ, Chen XJ, Bai JY, Jin J, Cui H*, Zhao ZX*. Butyrolactone and sesquiterpene derivatives as inhibitors of iNOS from the roots of Lindera glauca. Bioorganic Chemistry, 2021, 111: 104871.

2.Jiang SQ, Shen XT, Xuan SX, Yang B, Ruan QF, Cui H, Zhao ZX*, Jin J*. Serum and colon metabolomics study reveals the anti-ulcerative colitis effect of Croton crassifolius Geisel. Phytomedicine, 2021, 87: 153570.

3. Tang YQ, Chen XC, Zhou YW, Zhao M, He JX, Liu YN, Chen GY, Zhao ZX*, Cui H*. Furanaspermeroterpenes A and B, two unusual meroterpenoids with a unique 6/6/6/5/5 pentacyclic skeleton from the Marine-derived fungus Aspergillus terreus GZU-31-1. Bioorganic Chemistry, 2021, 114: 105111.

4. Yang B#, Xuan SX#, Ruan QF, Jiang SQ, Cui H, Zhu LP, Luo X, Jin J*, Zhao ZX*. UPLC/Q-TOF-MS/MS-based metabolomics revealed the lipid-lowering effect of Ilicis Rotundae Cortex on high-fat diet induced hyperlipidemia rats. Journal of Ethnopharmacology, 2020, 256: 112784.

5. Ruan QF#, Jiang SQ#, Zheng XY, Tang YQ, Yang B, Yi T, Jin J, Cui H*, Zhao ZX*. Pseudoguaianelactones A-C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2. Chemical Communications, 2020, 56(10): 1517-1520.

6. Tang YQ#, Liu YN#, Ruan QF, Zhao M, Zhao ZX*, Cui H*. Aspermeroterpenes A–C: Three Meroterpenoids from the Marine-Derived Fungus Aspergillus terreus GZU-31-1. Organic Letters, 2020, 22(4): 1336-1339.

7. Zhao M#, Ruan QF#, Pan WC, Tang YQ, Zhao ZX*, Cui H*. New polyketides and diterpenoid derivatives from the fungus Penicillium sclerotiorum GZU-XW03-2 and their anti-inflammatory activity. Fitoterapia, 2020, 143: 104561.

8. Yang B, Li H, Ruan QF, Xuan SX, Chen XJ, Cui H, Liu ZQ, Jin J*, Zhao ZX*. Effects of gut microbiota and ingredient-ingredient interaction on the pharmacokinetic properties of rotundic acid and pedunculoside. Planta Medica, 2019, 85(9-10): 729-737.

9. Ruan QF, Zhou XH, Jiang SQ, Yang B, Jin J, Cui H, Zhao ZX*. Caesalminaxins O-T, cassane diterpenoids from the seeds of Caesalpinia minax and their anti-inflammation. Fitoterapia, 2019, 134: 50-57.

10. Liu YN, Ruan QF, Jiang SQ, Qu Y, Chen JY, Zhao M, Yang B, Liu YX, Zhao ZX*, Cui H. Cytochalasins and polyketides from the fungus Diaporthe sp. GZU-1021 and their anti-inflammatory activity. Fitoterapia, 2019, 137: 104187.

11. Yang B, Zhu JP, Rong L, Jin J, Cao D, Li H, Zhou XH, Zhao ZX*. Triterpenoids with antiplatelet aggregation activity from Ilex rotunda. Phytochemistry, 2018, 145: 179-186.

12. Qiu MS, Jin J, Zhou L, Zhou W, Liu YX, Tan QL, Cao D, Zhao ZX*. Diterpenoids from Croton crassifolius include a novel skeleton possibly generated via an intramolecular [2+2]-photocycloaddition reaction. Phytochemistry, 2018, 145: 103-110.

13. Li H, Yang B, Cao D, Zhou L, Wang Q, Rong L, Zhou XH, Jin J*, Zhao ZX*. Identification of rotundic acid metabolites after oral administration to rats and comparison with the biotransformation by Syncephalastrum racemosum AS 3.264. Journal of Pharmaceutical and Biomedical Analysis, 2018, 150: 406-412.

14. Cao D, Wang Q, Jin J, Qiu MS, Zhou L, Zhou XH, Li H, Zhao ZX*. Simultaneous qualitative and quantitative analyses of triterpenoids in Ilex pubescens by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Phytochemical Analysis, 2018, 29(2): 168-179.

15. Cao D, Xu CC, Xue YY, Ruan QF, Yang B, Liu ZQ, Cui H, Zhang L, Zhao ZX*, Jin J*. The therapeutic effect of Ilex pubescens extract on blood stasis model rats according to serum metabolomics. Journal of Ethnopharmacology, 2018, 227: 18-28.


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